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It is released in pulses, mostly at night during deep sleep, with the largest pulse typically occurring in the first 60 to 90 minutes after sleep onset

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The STEP 1 trial showed that 86.4 percent of participants achieved at least 5 percent weight loss, 69.1 percent reached 10 percent, 50.5 percent hit 15 percent, and 32 percent achieved 20 percent or greater weight loss